Bench-Scale Compact Bioreactors & Fermentors

BenchTop Compact Bioreactors & Fermentors

Easy to use, versatile, small footprint, GMP validatable

Kbiotech Bio-Book Compact is a new line of latest generation Bioreactors that allow for the growth and cultivation of cells, microorganisms, and other biological systems in controlled conditions. They are designed to be small and portable, making them ideal for laboratory research, development but also for advanced bioprocessing and small-scale GMP production.

Compact bioreactors vessel are available in a variety of sizes and capacities. The smallest models can hold a few as 50 milliliters of culture medium, while the largest models can hold up to 20 or 30 litres, You can interchange different types of autoclavable Glass and Stainless Steel vessels but also Disposable vessels (click here for more informations). Compact bioreactors are typically equipped with a mechanical agitation system or magnetic stirring system on request with a choice of rushton, pitched, marine blade impellers for up or down flow as well as customizable impellers. The Compact control system is equipped with an accurate liquid dosing system for nutrients and additives with variable speed stepper pumps and gas mixing with Massflow meters or Rotameters with selectable flow rate based on your application. The Compact control unit is equipped with standard measurements and controls such as Temperature, PH, dissolved oxygen, foam & level but also already provides additional channels for the interface of auxiliary sensors such as for the measurement of Biomass Turbidity, Capacitance, O2/CO2/CH4/Methane gas analyzers, dissolved CO2 and other online devices such as Glucose.

Compact benchtop bioreactors are available in Single and Twin versions with two vessel for parallel and simultaneous operations to increase throughput, improve reproducibility and reduce costs.

Compact Parallel Bioreactors & Fermentors

Lab efficiency: Small footprint Bioreactor occupying a truly reduced surface of 280x400x600mm WxDxH or 11.0×15.75×24.4 inches (US) to overcome the issue of space limitations of many laboratories.

KBiotech Bioflex SCADA Supervisory Control and Data Acquisition software, is used to monitor and control your bioprocesses. Bioflex SCADA software typically runs on a computer and communicates with the Compact controllers as remote terminal unit over a network. In fact, through the Bioflex Software you can remotely monitor and control single or parallel bioreactors units with protected access wherever you are. Bioflex Scada provides a number of features including; Data Acquisition, Real time monitoring, Process control, Alarm management, Historical data logging, Data batch record and export Bioflex SCADA software is an essential tool as it allows operators to monitor and control simple and complex processes efficiently and effectively to facilitate and speed up process development and scale up from the research and optimization phase to pilot production and industrial manufacturing.

KBiotech Compact bioreactors offer a number of advantages over traditional bioreactors, including:

Smaller size and portability
Single and Parallel operations
Scale throughput for laboratories or GMP Production
Customizable

Various types of impellers available and customizable based on your application

Maintenance free

brushless motor with mechanical mixing or magnetic drive with a wide working range from 0 to 2000 rpm

Improved benchtop
Interchangeability of glass

Steel and disposable vessels from 50ml to 30 litres

Connectivity

Ease of connection to external networks and databases via OPC UA interface.

Simplicity

Bioflex SCADA Software developed as an intuitive and powerful user interface to offer maximum flexibility and reliability but minimize your learning curve

Ease of use
Hig-Pressure Proficiency

Capability of working with High Pressure vessels for special applications such as Biogas or others

Versatility

A high level of flexibility and connectivity for many sensors, analyzers and measuring devices such as PH,DO,T°,P°, Level, Foam, Weight but also Turbidity, Capacitance, O2/CO2/H2/CH4 gas analysis, Glucose and others

Here are some examples of applications for Compact Bioreactors

General applications:

  • Cell culture
    Compact bioreactors can be used to culture a variety of cells, including mammalian cells, insect cells, and yeast cells.
  • Microorganism culture
    Compact bioreactors can be used to culture a variety of microorganisms, such as bacteria, yeast, and algae.
  • Biocatalysis
    Compact bioreactors can be used to carry out biocatalytic reactions using enzymes or whole cells.
  • Drug discovery
    Compact bioreactors can be used to screen drug candidates for their effects on cells or microorganisms.
  • Education
    Compact bioreactors can be used to teach students about cell culture, microbiology, and biocatalysis.

Alternative foods:

  • Dairy products
  • Synthetic meat cell culturing
  • Food ingredients
  • Plant cell culture

Biopharmaceutical applications:

  • Cell Line Developments
  • Media optimization
  • Process scale-down
  • Biosimilars
  • Monoclonal Antibodies
  • Vaccines
  • mRNA Production
  • Proteins

Renewables:

  • Biofuels
  • Bioplastic
  • Biopolymers
  • Biogas
  • Biomolecules
  • Wastewater remediation

Top features

  • PLC technology with CPU optimized for fast data processing
  • Alternate Glass, Single-use vessels starting at 50 mL w/v to 30 L volume
  • Upgradable with in-situ sterilizable vessels from 3 L to 50 L
  • Single or Twin vessels configuration
  • Bioflex SCADA Software for process control and data management for individual or parallel systems
  • 4 built-in fixed or variable-speed peristaltic pumps,
  • 4 Rotameters or Mass flow controllers with gas mixing strategies for cell culture and fermentation
  • Digital and Analog interface for standard sensors: pH, Dissolved Oxygen, Temperature, Level, Foam, ORP, Conductivity
  • On board I/O’s for easy integration of online analytics: Biomass sensors, Gas analyzers, Mass Balance, automated samplers and multi-assay analyzers
  • Chiller integration for accurate temperature control, eliminate inconvenient water supply pipes in your lab
  • OPC connectivity to exchange data with third-party software
  • Simplicity of use and maintenance
  • Validatable for GLP and GMP use
  • Sales and service available worldwide

Interchangeable vessels, total volume

Benchtop Compact control units allow Glass, Disposable and Steel vessel that can be easily swapped out for another. This can be useful for a variety of purposes, such as

  • Portability and Versatility
    Interchangeable vessels can be used for a variety of different tasks, depending on the process requirements and scalability. This can save you from having to buy and carry multiple control unit for each vessels.
  • Efficiency
    Interchangeable vessels can make your work more efficient, as you can quickly swap out the vessel that you need without having to stop and change control unit.

We produce autoclavable glass, steel and single use vessels for various applications from animal cell cultures, insect cells, stem cells, bacterial fermentations, yeasts, biogas, and many other applications. 

Choose the type of vessel that’s right for you:

KBiotech new glass vessel design feature autoclavable borosilicate jacketed or single glass body with dished or round bottom, stainless steel head plates compatibility with all existing probes, dip tubes, spargers and impellers. The dishwasher-proof stirrer shaft and glass vessel fixation make it easy to clean, and a special version with a bottom drain is available for perfusion applications.

Jacketed and Single Wall Vessels.
Bioreactors 2:1 L/D ratio, Fermenters 3:1

Various accessories are also available based on the type of application and process such as marine, pitched blade, axial, radial, rushton impellers, safe sampler and perfusion systems, sterile liquids and gases additions for feedbatch and continuous application.

KBiotech Single-Use vessels allow scalable cell culture and fermentation from research to production. These rigid-wall stirred-tank single-use vessels have been specifically designed and optimized for cultivation suspended, adherent cells, microbial, bacterial fermentation in batch, feed batch and continuous / perfusion culture.

Jacketed and Single Wall Vessels.
Bioreactors 2:1 L/D ratio, Fermenters 3:1

KBiotech offer pre-assembled Steel bioreactors and fermenters packages or custom made solutions based on detailed requirements. Our laboratory systems are designed to guarantee better performances and improve process conditions like scaling up or scaling down, mixing and oxygen transfer, heating/cooling thermal transfer, sterility and cleaning procedures to optimize manufacturing time and costs saving.

Water jacketed and single wall Steel vessels.
Bioreactors 2:1 L/D ratio, Fermenters 3:1

Various accessories are also available based on the type of application and process such as marine, pitched blade, axial, radial, rushton impellers, safe sampler and perfusion systems, sterile liquids and gases additions for feedbatch and continuous application.

Thermo Chiller

KBiotech Thermo Chiller, highly performing heating and cooling system

The Bio-Book controller allows the integration of KBiotech Thermo Chiller with innovative technology and optimal regulation of the temperature from 15°C to 90°C with a high degree of precision up to 0.1°C, as well as substantial savings on water and energy. More powerful chillers are also available to cool down to +4°C.

Bio-Book Compact control unit technical data

  • Power supply: 120 – 240 (±10 %) V, 50/60 Hz, 10 A, Single Phase
  • Water supply: Quick-connect; 10 psig (0.69 barg)
  • Communication: USB, Ethernet, OPC UA (SCADA, IP Network)
  • User Interface: 14” Touchscreen or desktop PC
  • Dimensions: (W × D × H): 28.0 × 40.0 × 60.0 cm / 11 × 15.75 × 24.4 inches
  • Weight w/o accessories: 15.5 kg / 34.1 lbs

Online process analyzers to improve product development and quality control monitoring

Online analyzers are instruments that are used to measure the physical and chemical properties of a process such as Biomass, Gas analysis, nutrients and dissolved CO2 in real time. They are typically installed directly in the process line or directly in contact with the liquid, and provide continuous data on the composition and quality of the bioprocess and to ensure compliance with Good Manufacturing Practices. The KBiotech Online analyzers offer a number of advantages over traditional laboratory analysis methods, including:

Real-Time Data

Online analyzers provide continuous data on the composition and quality of the process, which allows operators to make immediate adjustments to the process if necessary.

Accuracy

Online analyzers are typically very accurate, and can detect changes in the process that would be difficult or impossible to detect with traditional laboratory analysis methods.

Efficiency

Online analyzers can save time and money by eliminating the need for manual sampling and laboratory analysis.

Analyzers connectivity for feedback control and process optimization

All online analyzers can be connected to our SCADA Bioflex Software for online data acquisition, feedback control and predictive data analysis for process optimization and risk-based actions, PAT compliance.

gas analizer

KB-Ferm Gas Analyzer

KG-Ferm KBiotech Gas analyzer for online monitoring of exhaust gases for the calculation of respiratory quotients and metabolic activity. Available gases: O2, CO2, CH4, H2, Ethanol. Contact us for more details.

All online analyzers can be connected to our SCADA Bioflex Software for online data acquisition, feedback control and predictive data analysis for process optimization and risk-based actions, PAT compliance.

Online biomass sensor

Online Biomass Sensors

KB-Dencitee Total cell density sensor, in-situ measurement of total cell density using transmittance and reflectance of near-infrared light in low and high cell density applications.

KB-Incyte-VBC real-time monitoring of viable cell biomass based on capacitance measurement for cell culture and fermentation process.

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