CIP/SIP Pilot
In situ cleaning and sterilising system for Autoclavable and SIP Bioreactors
Kbiotech supplies a range of standardized & customized Pilot Bioreactors & Fermenters for your microbial culture needs – bacterial or yeast – as well as cell culture from 20 Liter to 500 Liters volume.
Industrial design, Flexible automation, software and vessel solutions for pharmaceutical, biotechnological and food industries.
All our systems can be fully documented for GLP and cGMP usage and are supplied with an extensive package of documentation to support validation and quality by design.
Applications
General applications:
- Pilot Production
- Clinical manufacturing
- Biopharmaceuticals
- Biosimilars
- Monoclonal Antibodies
- Vaccines
- mRNA Production
- Plasma and Blood derivates
- Proteins
- Cell Therapy
Alternative foods:
- Dairy products
- Synthetic meat cell culturing
- Food ingredients
- Plant cell culture
Renewables:
- Biofuels
- Bioplastic
- Biopolymers
- Biogas
- Biomolecules
- Wastewater remediation
Top features
- Standard or Customized solutions based on specific client application and budget
- Pilot scale culture vessels are available in bacteriological or cell cultivation configurations in the following sizes: 20, 30, 40, 50, 70, 80, 100, 130, 150, 200, 250, 300, 400 and 500 litre volume w/v
- Flexible design with H/D ratio 3:1, 2:1, 1.5:1 or customized for multi-purpose applications
- High quality stainless steel 316 L tanks, inner surface finish: ≤ 0.2 µm, ≤ 0.4 µm, ≤ 0.6 µm, ≤ 0.8 µm
- Automated empty and full sterilization with optimal thermoregulation
- Mechanical sealed or Magnetic coupler mixing solutions, top or bottom mounted as per your requirements with high torque or gentle mixing and interchangeable impellers such as Rusthon, Marine, Pitched blade, anchor or customized
- Leading industry components for automation, electronics, sensors, valves and gas mixing, among others, offering quality without compromise
- Excellent design eliminates casual operator contact
- Powerful SCADA Software to simultaneously manage and control single and multiple bioreactors
- Fully automatic in situ sterilisation with integrated steam generator
- Integrated or external CIP cleaning system
- Modular design and interconnectivity with external devices provide individual solutions.
- Manufacturing compliance to international standards for pressurized tanks and electrical equipment
- GLP and GMP validatable
Online Analyzers available to optimize process control
KG-Ferm KBiotech Gas analyzer for online monitoring of exhaust gases for the calculation of respiratory quotients and metabolic activity. Gases available: O2, CO2, CH4, H2, CO; more available on request.
KB-Incyte-VBC real-time monitoring of viable cell biomass based on capacitance measurement for cell culture and fermentation process.
All online analyzers can be connected to our Bioflex Software for online data acquisition, feedback control and predictive data analysis for process optimization and risk-based actions, PAT compliance.
KBiotech CIP/SIP System for in situ steam sterilization and cleaning
The All-in-one solution from KBiotech is a unique device in a single compact and integrated system for the sterilization and cleaning of your bioreactor or fermenter.