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1.000 Bioreactor

Industrial SIP Bioreactors

Stainless-Steel Fermenters (500 L – 50,000 L)

KBiotech’s Industrial BioSip Bioreactors bridge the final step from pilot systems to large-scale GMP production.

Engineered for long-term reliability, process consistency, and regulatory compliance, each unit combines automated SIP/CIP, electropolished stainless-steel vessels, and the BIOFLEX SCADA platform for complete control and data integrity across every batch.

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Why Choose Industrial SIP Bioreactors?

Scale without limits — precision, reliability, and full GMP compliance.

Flexible Capacity

From 500 L pilot lines to 50,000 L+ production fermenters, all geometry-matched for reproducible scale-up.

Automated SIP & CIP

Integrated clean-steam generation and cycle automation reduce turnaround by up to 60 %.

GMP-Certified Design

Built to ASME BPE, PED, CE, ISO 9001, and 21 CFR Part 11 standards for full global compliance.

Technical Specifications

Volume Range

500 L – 50,000 L (expandable to 100,000 L)

Vessel Material

316L stainless steel, Ra ≤ 0.2–0.4 µm, electropolished

Sterilization & Cleaning

fully automated SIP/CIP with clean steam

Temperature Range

4 – 150 °C (±0.1 °C)

Pressure Rating

up to 15+ barg

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PLC Integration for Pilot & Industrial Bioreactors

Flexible control architecture for every scale — from pilot to full production.

Siemens Integration

  • OPC-UA & PROFINET connectivity
  • Real-time monitoring of pH, DO, temperature, pressure, biomass
  • Advanced recipe builder for batch, fed-batch, perfusion
  • 21 CFR Part 11 compliant audit trails and secure login

Rockwell Integration

  • Seamless EtherNet/IP & OPC-UA communication
  • Robust HMI and supervisory control
  • Enterprise integration with MES, ERP, and LIMS
  • Remote access from desktop, tablet, or mobile

Emerson Integration

  • DeltaV and PACSystems compatibility
  • Connectivity via Modbus, OPC-UA, REST API
  • Centralized dashboards with advanced reporting
  • Scalable for pilot through full-scale manufacturing

SmartBioFlex™ Control

Elevate your Industrial SIP Bioreactors with BioFlex™ Software — a powerful, intuitive platform that simplifies process control, ensures regulatory compliance, and delivers real-time insights for smarter bioprocessing.

bioflex

Seamless Integration

SmartBioFlex™ combines an industrial distributed control core with an intuitive web interface.

From Recipe to Data Export

Users build multiphase recipes via draganddrop cascades, monitor critical parameters remotely and export encrypted data directly to LIMS.

Audit Trails and Onboarding

A complete audit trail supports regulatory inspections, while onboarding guidance assists less experienced operators.

Inline Analytics & PAT Modules

Enhance process understanding with real-time monitoring and control directly integrated into your bioreactor.

  • KG-FERM: Off-gas analysis (O₂, CO₂, CH₄, H₂, CO)
  • KBIO-TBD: Optical and capacitance biomass monitoring
  • LIVE-CELL™: Inline cell viability and density measurement
  • Raman Spectroscopy: Molecular fingerprinting for metabolites and product profiling
  • Automated Sampling Ports: Sterile inline collection for offline QC Advanced PAT tools for data-driven optimization and consistent bioprocess performance.

Continuous Processing & Downstream Integration

Achieve upstream–downstream continuity on your benchtop with KBIOTECH’s continuous bioprocess solutions.

  • ATF: Ultra-high cell densities with low-shear circulation.
  • TFF: Stable medium exchange for extended continuous runs.
  • Smart Harvest: Automated, weight-based fluid control for consistent yields. Efficient, scalable, and fully integrated from culture to harvest.
Downloads:
SmartBioFlex™ Software
Tecnnical Data Sheet

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Call us or request a back call to contact our specialists

+41 916 300 115

For presales questions and your order status email us at

sales@kbiotech.ch
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Got questions?
Well, we’ve got answers

Yes — compliant with ASME BPE, PED, CE, ISO 9001, and 21 CFR Part 11.

Absolutely — modular architecture supports up to 50,000 L+ without redesign.

Yes — supports Siemens, Rockwell, DeltaV, and third-party automation.

Yes — full DQ, IQ, OQ, FAT, SAT, and PQ packages included.

Yes — worldwide installation, training, and remote diagnostics are standard.